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The second-year running back led the league with 381 touches last season and finished as the RB4 in half-point PPR formats. We wouldn't be surprised to see Harris as the RB1 when the 2022 season concludes. Najee Harris, Pittsburgh Steelers (Bye Week: 9) Those numbers are worthy of an early first-round pick. Cook averaged 22 touches per game and 15.2 fantasy points per game when healthy last season.

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The three-time Pro Bowler saw his TD total dip from 17 in 2021 to six in 2022 and missed four games. Dalvin Cook, Minnesota Vikings (Bye Week: 7)Ĭook owners may have a bitter taste in their mouths heading into this year's draft. There's obvious injury concern heading into 2022, especially given his enormous workload, but Henry should be considered one of the best running back options on the board until proven otherwise.

He led all running backs in PPR points per game (23.4) through those eight weeks. Henry finished as the RB20 last season despite playing in only eight games due to injury. Derrick Henry, Tennessee Titans (Bye Week: 6) In an offense that's expected to fire on all cylinders again in 2022, Ekeler will be given every opportunity to shine. He's no slouch in the running game either as he tallied 911 yards for another 12 TDs. He racked up 70 receptions out of the backfield for 647 yards and eight TDs. If healthy, Ekeler is about as safe as a top-five draft pick as you can get in PPR formats. Austin Ekeler, Los Angeles Chargers (Bye Week: 8) We still think he's worth the investment, but be sure to grab Chuba Hubbard later on in your draft as an insurance policy. You're spending a top-three pick on a potential league-winner who also has a high chance of derailing your season with an injury.

You know what you're getting with Christian McCaffrey at this point. Christian McCaffrey, Carolina Panthers (Bye Week: 13)